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The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5′Untranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression

There is compelling support for limiting expression of alpha-synuclein (α-syn) in the brains of Parkinson's disease (PD) patients. An increase of SNCA gene copy number can genetically cause familial PD where increased dose of this pathogenic protein correlates with severity of symptoms (triplic...

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Autori principali: Mikkilineni, Sohan, Cantuti-Castelvetri, Ippolita, Cahill, Catherine M., Balliedier, Amelie, Greig, Nigel H., Rogers, Jack T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368596/
https://ncbi.nlm.nih.gov/pubmed/22693681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/142372
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