Upregulation of RNase E activity by mutation of a site that uncompetitively interferes with RNA binding

Escherichia coli RNase E contains a site that selectively binds to RNAs containing 5′-monophosphate termini, increasing the efficiency of endonucleolytic cleavage of these RNAs. Random mutagenesis of N-Rne, the N-terminal catalytic region of RNase E, identified a hyperactive variant that remains pre...

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Detalhes bibliográficos
Main Authors: Go, Hayoung, Moore, Christopher J, Lee, Minho, Shin, Eunkyoung, Jeon, Che Ok, Cha, Chang-Jun, Han, Seung Hyun, Kim, Su-Jin, Lee, Sang-Won, Lee, Younghoon, Ha, Nam-Chul, Kim, Yong-Hak, Cohen, Stanley N, Lee, Kangseok
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360077/
https://ncbi.nlm.nih.gov/pubmed/22186084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.8.6.18036
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