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Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial–mesenchymal transition

Sialyl Lewis x (sLe(x)) and sialyl Lewis a (sLe(a)) glycans are expressed on highly metastatic colon cancer cells. They promote extravasation of cancer cells and tumor angiogenesis via interacting with E-selectin on endothelial cells. Recently, epithelial–mesenchymal transition (EMT) has been noted...

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Hlavní autoři: Sakuma, Keiichiro, Aoki, Masahiro, Kannagi, Reiji
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356678/
https://ncbi.nlm.nih.gov/pubmed/22547830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111135109
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