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Kinetic mechanism for HIV-1 neutralization by antibody 2G12 entails reversible glycan binding that slows cell entry

Despite structural knowledge of broadly neutralizing monoclonal antibodies (NMAbs) complexed to HIV-1 gp120 and gp41 envelope glycoproteins, virus inactivation mechanisms have been difficult to prove, in part because neutralization assays are complex and were previously not understood. Concordant wi...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Platt, Emily J., Gomes, Michelle M., Kabat, David
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356642/
https://ncbi.nlm.nih.gov/pubmed/22547820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109728109
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