Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera

A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2) gene, and both cell culture and mouse models have established a functional role for this mutation in the development of this disease. We desc...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kraus, Manfred, Wang, Yuxun, Aleksandrowicz, Dan, Bachman, Eric, Szewczak, Alexander A., Walker, Deborah, Xu, Lin, Bouthillette, Melaney, Childers, Kaleen M., Dolinski, Brian, Haidle, Andrew M., Kopinja, Johnny, Lee, Linda, Lim, Jongwon, Little, Kevin D., Ma, Yanhong, Mathur, Anjili, Mo, Jan-Rung, O’Hare, Erin, Otte, Ryan D., Taoka, Brandon M., Wang, Wenxian, Yin, Hong, Zabierek, Anna A., Zhang, Weisheng, Zhao, Shuxia, Zhu, Joe, Young, Jonathan R., Marshall, C. Gary
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356383/
https://ncbi.nlm.nih.gov/pubmed/22623993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037207
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