Synthesis, thermal stability and reactivity towards 9-aminoellipticine of double-stranded oligonucleotides containing a true abasic site.

A 13 mers abasic oligonucleotide was synthetized. It was therefore possible to compare thermal stability and reactivity of duplex oligonucleotides either with an apurinic/apyrimidinic site or without any lesion. An important decrease in the melting temperature appeared for duplexes with an abasic si...

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Bibliographic Details
Main Authors: Bertrand, J R, Vasseur, J J, Rayner, B, Imbach, J L, Paoletti, J, Paoletti, C, Malvy, C
Format: Artigo
Language:Inglês
Published: 1989
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC335302/
https://ncbi.nlm.nih.gov/pubmed/2602153
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