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APP physiological and pathophysiological functions: insights from animal models
The amyloid precursor protein (APP) has been under intensive study in recent years, mainly due to its critical role in the pathogenesis of Alzheimer's disease (AD). β-Amyloid (Aβ) peptides generated from APP proteolytic cleavage can aggregate, leading to plaque formation in human AD brains. Poi...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351924/ https://ncbi.nlm.nih.gov/pubmed/21769132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.116 |
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