Antibody to α4 Integrin Suppresses Natural Killer Cells Infiltration in Central Nervous System in Experimental Autoimmune Encephalomyelitis

Natalizumab inhibits the influx of leukocytes into the central nervous system (CNS) via blockade of alpha-4 subunit of very late activation antigen (VLA)-4. The association of natalizumab therapy with progressive multifocal leukoencephalopathy (PML) suggests a disturbance of CNS immune surveillance...

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Bibliographic Details
Main Authors: Gan, Yan, Liu, Ruolan, Wu, Wei, Darin, Okuda, Bomprezzi, Roberto, Shi, Fu-Dong
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351567/
https://ncbi.nlm.nih.gov/pubmed/22503411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.03.011
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