Antibody to α4 Integrin Suppresses Natural Killer Cells Infiltration in Central Nervous System in Experimental Autoimmune Encephalomyelitis

Natalizumab inhibits the influx of leukocytes into the central nervous system (CNS) via blockade of alpha-4 subunit of very late activation antigen (VLA)-4. The association of natalizumab therapy with progressive multifocal leukoencephalopathy (PML) suggests a disturbance of CNS immune surveillance...

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Hauptverfasser: Gan, Yan, Liu, Ruolan, Wu, Wei, Darin, Okuda, Bomprezzi, Roberto, Shi, Fu-Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351567/
https://ncbi.nlm.nih.gov/pubmed/22503411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.03.011
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