Broad-Spectrum β-Lactam Antibiotics for Treating Experimental Peritonitis in Mice Due to Klebsiella pneumoniae Producing the Carbapenemase OXA-48

A lethal peritonitis model was induced in mice with a Klebsiella pneumoniae isolate producing the carbapenemase OXA-48. Administration of a single dose (up to 100 mg/kg) of the antibiotic piperacillin-tazobactam, imipenem-cilastatin, ertapenem, or cefotaxime had little or no impact on lethality. Cef...

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Bibliographic Details
Main Authors: Mimoz, Olivier, Grégoire, Nicolas, Poirel, Laurent, Marliat, Manuella, Couet, William, Nordmann, Patrice
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346608/
https://ncbi.nlm.nih.gov/pubmed/22330912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06069-11
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