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Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure

Single-minded 1 (Sim1) is a transcription factor necessary for development of the paraventricular nucleus of the hypothalamus (PVH). This nucleus is a critical regulator of appetite, energy expenditure and body weight. Previously we showed that Sim1(+/−) mice and conditional postnatal Sim1(−/−) mice...

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Библиографические подробности
Главные авторы: Xi, Dong, Gandhi, Nilay, Lai, Meizan, Kublaoui, Bassil M.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338647/
https://ncbi.nlm.nih.gov/pubmed/22558467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036453
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