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Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure
Single-minded 1 (Sim1) is a transcription factor necessary for development of the paraventricular nucleus of the hypothalamus (PVH). This nucleus is a critical regulator of appetite, energy expenditure and body weight. Previously we showed that Sim1(+/−) mice and conditional postnatal Sim1(−/−) mice...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3338647/ https://ncbi.nlm.nih.gov/pubmed/22558467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036453 |
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