Exposure–response relationship of AMG 386 in combination with weekly paclitaxel in recurrent ovarian cancer and its implication for dose selection

PURPOSE: To characterize exposure–response relationships of AMG 386 in a phase 2 study in advanced ovarian cancer for the facilitation of dose selection in future studies. METHODS: A population pharmacokinetic model of AMG 386 (N = 141) was developed and applied in an exposure–response analysis usin...

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Main Authors: Lu, Jian-Feng, Rasmussen, Erik, Karlan, Beth Y., Vergote, Ignace B., Navale, Lynn, Kuchimanchi, Mita, Melara, Rebeca, Stepan, Daniel E., Weinreich, David M., Sun, Yu-Nien
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2012
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337406/
https://ncbi.nlm.nih.gov/pubmed/22210018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1787-5
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