Cysteamine Suppresses Invasion, Metastasis and Prolongs Survival by Inhibiting Matrix Metalloproteinases in a Mouse Model of Human Pancreatic Cancer

BACKGROUND: Cysteamine, an anti-oxidant aminothiol, is the treatment of choice for nephropathic cystinosis, a rare lysosomal storage disease. Cysteamine is a chemo-sensitization and radioprotection agent and its antitumor effects have been investigated in various tumor cell lines and chemical induce...

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Bibliographic Details
Main Authors: Fujisawa, Toshio, Rubin, Benjamin, Suzuki, Akiko, Patel, Prabhudas S., Gahl, William A., Joshi, Bharat H., Puri, Raj K.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332081/
https://ncbi.nlm.nih.gov/pubmed/22532830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034437
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