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Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis

Modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar, 4-amino-4-deoxy-L-arabinose (L-Ara4N), is a strategy adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system. L-Ara4N biosynthesis is therefore a...

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Bibliographic Details
Main Authors: Williams, Gareth J., Breazeale, Steven D., Raetz, Christian R. H., Naismith, James H.
Format: Artigo
Language:Inglês
Published: 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326539/
https://ncbi.nlm.nih.gov/pubmed/15809294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M501534200
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