Pharmacokinetic Evaluation of Intranasally Administered Vinyl Polymer-Coated Lorazepam Microparticles in Rabbits

The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and thus, innovative epithelial presentation is required. The aim of this study w...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhao, Yanjun, Brown, Marc B., Khengar, Rajeshree H., Traynor, Matthew J., Barata, Pedro, Jones, Stuart A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer US 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326174/
https://ncbi.nlm.nih.gov/pubmed/22396304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9325-x
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