Multistep Ion Channel Remodeling and Lethal Arrhythmia Precede Heart Failure in a Mouse Model of Inherited Dilated Cardiomyopathy

BACKGROUND: Patients with inherited dilated cardiomyopathy (DCM) frequently die with severe heart failure (HF) or die suddenly with arrhythmias, although these symptoms are not always observed at birth. It remains unclear how and when HF and arrhythmogenic changes develop in these DCM mutation carri...

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Autors principals: Suzuki, Takeshi, Shioya, Takao, Murayama, Takashi, Sugihara, Masami, Odagiri, Fuminori, Nakazato, Yuji, Nishizawa, Hiroto, Chugun, Akihito, Sakurai, Takashi, Daida, Hiroyuki, Morimoto, Sachio, Kurebayashi, Nagomi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325934/
https://ncbi.nlm.nih.gov/pubmed/22514734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035353
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