B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease

BACKGROUND: Langerhans cell histiocytosis (LCH) features inflammatory granuloma characterised by the presence of CD1a+ dendritic cells or ‘LCH cells’. Badalian-Very et al. recently reported the presence of a canonical (V600E)B-RAF mutation in 57% of paraffin-embedded biopsies from LCH granuloma. Her...

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Autores principales: Satoh, Takeshi, Smith, Alexander, Sarde, Aurelien, Lu, Hui-chun, Mian, Sophie, Trouillet, Celine, Mufti, Ghulam, Emile, Jean-Francois, Fraternali, Franca, Donadieu, Jean, Geissmann, Frederic
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323620/
https://ncbi.nlm.nih.gov/pubmed/22506009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033891
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