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Total Synthesis of Lepadiformine Alkaloids using N-Boc α-Amino Nitriles as Trianion Synthonsa

Lepadiformine A, B and C were synthesized in enantiomerically pure form using a reductive cyclization strategy. N-Boc α-amino nitriles were deprotonated and alkylated with enantiomerically pure dibromides to afford the first ring. The products were manipulated to introduce phosphate leaving-groups,...

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Autori principali: Perry, Matthew A., Morin, Matthew D., Slafer, Brian W., Rychnovsky, Scott D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321086/
https://ncbi.nlm.nih.gov/pubmed/22413935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo300161x
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