Chronic Inhibition of ERK1/2 Signaling Improves Disordered Bone and Mineral Metabolism in Hypophosphatemic (Hyp) Mice

The X-linked hypophosphatemic (Hyp) mouse carries a loss-of-function mutation in the phex gene and is characterized by hypophosphatemia due to renal phosphate (Pi) wasting, inappropriately suppressed 1,25-dihydroxyvitamin D [1,25(OH)(2)D] production, and rachitic bone disease. Increased serum fibrob...

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Autores principales: Zhang, Martin Y. H., Ranch, Daniel, Pereira, Renata C., Armbrecht, Harvey J., Portale, Anthony A., Perwad, Farzana
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2012
Materias:
Growth Factors-Cytokines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320256/
https://ncbi.nlm.nih.gov/pubmed/22334725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1831
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