Host Differences in Influenza-Specific CD4 T Cell and B Cell Responses Are Modulated by Viral Strain and Route of Immunization

The antibody response to influenza infection is largely dependent on CD4 T cell help for B cells. Cognate signals and secreted factors provided by CD4 T cells drive B cell activation and regulate antibody isotype switching for optimal antiviral activity. Recently, we analyzed HLA-DR1 transgenic (DR1...

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Detalhes bibliográficos
Main Authors: Sundararajan, Aarthi, Huan, Lifang, Richards, Katherine A., Marcelin, Glendie, Alam, Shabnam, Joo, HyeMee, Yang, Hongmei, Webby, Richard J., Topham, David J., Sant, Andrea J., Sangster, Mark Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311631/
https://ncbi.nlm.nih.gov/pubmed/22457834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034377
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