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ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila
To investigate the mechanistic basis for central nervous system (CNS) neurodegeneration in the disease ataxia–telangiectasia (A-T), we analyzed flies mutant for the causative gene A-T mutated (ATM). ATM encodes a protein kinase that functions to monitor the genomic integrity of cells and control cel...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306708/ https://ncbi.nlm.nih.gov/pubmed/22355133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110470109 |
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