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Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis

Axonal transport deficits have been reported in many neurodegenerative conditions and are widely assumed to be an immediate causative step of axon and synapse loss. By imaging changes in axonal morphology and organelle transport over time in several animal models of amyotrophic lateral sclerosis (AL...

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Main Authors: Marinković, Petar, Reuter, Miriam S., Brill, Monika S., Godinho, Leanne, Kerschensteiner, Martin, Misgeld, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306689/
https://ncbi.nlm.nih.gov/pubmed/22371592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200658109
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