Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis

Axonal transport deficits have been reported in many neurodegenerative conditions and are widely assumed to be an immediate causative step of axon and synapse loss. By imaging changes in axonal morphology and organelle transport over time in several animal models of amyotrophic lateral sclerosis (AL...

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Bibliographic Details
Main Authors: Marinković, Petar, Reuter, Miriam S., Brill, Monika S., Godinho, Leanne, Kerschensteiner, Martin, Misgeld, Thomas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306689/
https://ncbi.nlm.nih.gov/pubmed/22371592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200658109
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