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AIDing the pursuit of IgA diversity
Direct evaluation of the contribution of somatic hypermutation (SHM) to mucosal immunity has been hampered by the lack of models able to dissociate SHM from class-switch recombination, which are both dependent on the cytidine deaminase AID. A new mouse AID model now demonstrates the critical role of...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3299005/ https://ncbi.nlm.nih.gov/pubmed/21321590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni0311-197 |
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