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A Drosophila model of GSS syndrome suggests defects in active zones are responsible for pathogenesis of GSS syndrome
We have established a Drosophila model of Gerstmann–Sträussler–Scheinker (GSS) syndrome by expressing mouse prion protein (PrP) having leucine substitution at residue 101 (MoPrP(P101L)). Flies expressing MoPrP(P101L), but not wild-type MoPrP (MoPrP(3F4)), showed severe defects in climbing ability an...
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| Päätekijät: | , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3298851/ https://ncbi.nlm.nih.gov/pubmed/20829230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq379 |
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