A Drosophila model of GSS syndrome suggests defects in active zones are responsible for pathogenesis of GSS syndrome

We have established a Drosophila model of Gerstmann–Sträussler–Scheinker (GSS) syndrome by expressing mouse prion protein (PrP) having leucine substitution at residue 101 (MoPrP(P101L)). Flies expressing MoPrP(P101L), but not wild-type MoPrP (MoPrP(3F4)), showed severe defects in climbing ability an...

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Bibliografiske detaljer
Main Authors: Choi, Jin-Kyu, Jeon, Yong-Chul, Lee, Dae-Weon, Oh, Jae-Min, Lee, Hyun-Pil, Jeong, Byung-Hoon, Carp, Richard I., Koh, Young Ho, Kim, Yong-Sun
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298851/
https://ncbi.nlm.nih.gov/pubmed/20829230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq379
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