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Diphenyl Urea Derivatives as Inhibitors of Transketolase: A Structure-Based Virtual Screening
Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold, found by applying structure-based virtual sc...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293897/ https://ncbi.nlm.nih.gov/pubmed/22403640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032276 |
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