Metformin Inhibits Nuclear Receptor TR4–Mediated Hepatic Stearoyl-CoA Desaturase 1 Gene Expression With Altered Insulin Sensitivity

OBJECTIVE: TR4 is a nuclear receptor without clear pathophysiological roles. We investigated the roles of hepatic TR4 in the regulation of lipogenesis and insulin sensitivity in vivo and in vitro. RESEARCH DESIGN AND METHODS: TR4 activity and phosphorylation assays were carried out using hepatocytes...

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Main Authors: Kim, Eungseok, Liu, Ning-Chun, Yu, I-Chen, Lin, Hung-Yun, Lee, Yi-Fen, Sparks, Janet D., Chen, Lu-Min, Chang, Chawnshang
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2011
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292323/
https://ncbi.nlm.nih.gov/pubmed/21478464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0393
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