IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice

Interleukin (IL-) 10 is a pleiotropic cytokine with broad immunosuppressive functions, particularly at mucosal sites such as the intestine and lung. Here we demonstrate that infection of BALB/c mice with respiratory syncytial virus (RSV) induced IL-10 production by CD4(+) and CD8(+) T cells in the a...

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Main Authors: Loebbermann, Jens, Schnoeller, Corinna, Thornton, Hannah, Durant, Lydia, Sweeney, Nathan P., Schuijs, Martijn, O'Garra, Anne, Johansson, Cecilia, Openshaw, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290561/
https://ncbi.nlm.nih.gov/pubmed/22393401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032371
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