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Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)
Computational design of small molecule putative inhibitors of Polo-like kinase 1 (Plk1) is presented. Plk1, which regulates the cell cycle, is often over expressed in cancers. Down regulation of Plk1 has been shown to inhibit tumor progression. Most kinase inhibitors interact with the ATP binding si...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Libertas Academica
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290105/ https://ncbi.nlm.nih.gov/pubmed/22399850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BBI.S8971 |
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