A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes

BACKGROUND: Drug-induced long QT syndrome (diLQTS) is an adverse drug effect that has an important impact on drug use, development, and regulation. Here, we tested the hypothesis that common variants in key genes controlling cardiac electrical properties modify the risk of diLQTS. METHODS AND RESULT...

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Main Authors: Kääb, Stefan, Crawford, Dana C., Sinner, Moritz F., Behr, Elijah R., Kannankeril, Prince J., Wilde, Arthur A. M., Bezzina, Connie R., Schulze-Bahr, Eric, Guicheney, Pascale, Bishopric, Nanette H., Myerburg, Robert J., Schott, Jean-Jacques, Pfeufer, Arne, Beckmann, Britt-Maria, Martens, Eimo, Zhang, Taifang, Stallmeyer, Birgit, Zumhagen, Sven, Denjoy, Isabelle, Bardai, Abdennasser, Van Gelder, Isabelle C., Jamshidi, Yalda, Dalageorgou, Chrysoula, Marshall, Vanessa, Jeffery, Steve, Shakir, Saad, Camm, A. John, Steinbeck, Gerhard, Perz, Siegfried, Lichtner, Peter, Meitinger, Thomas, Peters, Annette, Wichmann, H.-Erich, Ingram, Christiana, Bradford, Yuki, Carter, Shannon, Norris, Kris, Ritchie, Marylyn D., George, Alfred L., Roden, Dan M.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288202/
https://ncbi.nlm.nih.gov/pubmed/22100668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.111.960930
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