Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer, Inhibits Amyloid-β-Mediated Alzheimer's Disease-Associated Pathogenesis In Vitro and In Vivo

We have previously synthesized a series of hybrid compounds by linking ferulic acid to tacrine as multifunctional agents based on the hypotheses that Alzheimer's disease (AD) generates cholinergic deficiency and oxidative stress. Interestingly, we found that they may have potential pharmacologi...

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Hoofdauteurs: Pi, Rongbiao, Mao, Xuexuan, Chao, Xiaojuan, Cheng, Zhiyi, Liu, Mengfei, Duan, Xiaolu, Ye, Mingzhong, Chen, Xiaohong, Mei, Zhengrong, Liu, Peiqing, Li, Wenming, Han, Yifan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285653/
https://ncbi.nlm.nih.gov/pubmed/22384101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031921
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