Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate

BACKGROUND: Dendritic cells (DCs) are the most potent antigen-presenting cell population for activating tumor-specific T cells. Due to the wide range of methods for generating DCs, there is no common protocol or defined set of criteria to validate the immunogenicity and function of DC vaccines. METH...

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Bibliografiske detaljer
Main Authors: Chiang, Cheryl L-L, Maier, Dawn A, Kandalaft, Lana E, Brennan, Andrea L, Lanitis, Evripidis, Ye, Qunrui, Levine, Bruce L, Czerniecki, Brian J, Powell Jr, Daniel J, Coukos, George
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283529/
https://ncbi.nlm.nih.gov/pubmed/22082029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-198
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