The ADAMTS1 Protease Gene Is Required for Mammary Tumor Growth and Metastasis

A disintegrin and metalloprotease with thrombospondin motifs protein 1 (ADAMTS1) is a protease commonly up-regulated in metastatic carcinoma. Its overexpression in cancer cells promotes experimental metastasis, but whether ADAMTS1 is essential for metastatic progression is unknown. To address this q...

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Bibliographic Details
Main Authors: Ricciardelli, Carmela, Frewin, Kate M., Tan, Izza de Arao, Williams, Elizabeth D., Opeskin, Kenneth, Pritchard, Melanie A., Ingman, Wendy V., Russell, Darryl L.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2011
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260838/
https://ncbi.nlm.nih.gov/pubmed/22001177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.021
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