Pharmacodynamic Effects of Simulated Standard Doses of Antifungal Drugs against Aspergillus Species in a New In Vitro Pharmacokinetic/Pharmacodynamic Model

In conventional ΜΙC tests, fungi are exposed to constant drug concentrations, whereas in vivo, fungi are exposed to changing drug concentrations. Therefore, we developed a new in vitro pharmacokinetic/pharmacodynamic model where human plasma pharmacokinetics of standard doses of 1 mg/kg amphotericin...

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Autors principals: Meletiadis, Joseph, Al-Saigh, Rafal, Velegraki, Aristea, Walsh, Thomas J., Roilides, Emmanuel, Zerva, Loukia
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256091/
https://ncbi.nlm.nih.gov/pubmed/22064546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00662-11
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