Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

The circadian clock coordinates daily oscillations of essential physiological and behavioral processes. Conversely, aberrant clocks with damped amplitude and/or abnormal period have been associated with chronic diseases and aging. To search for small molecules that perturb or enhance circadian rhyth...

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Bibliographic Details
Main Authors: Chen, Zheng, Yoo, Seung-Hee, Park, Yong-Sung, Kim, Keon-Hee, Wei, Shuguang, Buhr, Ethan, Ye, Zeng-You, Pan, Hui-Lin, Takahashi, Joseph S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252927/
https://ncbi.nlm.nih.gov/pubmed/22184224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118034108
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