Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome

Response to immunosuppressive therapy (IST) in younger patients with myelodysplastic syndrome (MDS) has been linked to a T-cell-dominant autoimmune process that impairs hematopoiesis. Analysis of the age-adjusted CD4:CD8 ratio in 76 MDS patients compared with 54 healthy controls showed that inadequa...

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Autori principali: Zou, JX, Rollison, DE, Boulware, D, Chen, D-T, Sloand, EM, Pfannes, LV, Goronzy, JJ, Bai, F, Painter, JS, Wei, S, Cosgrove, D, List, AF, Epling-Burnette, PK
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252820/
https://ncbi.nlm.nih.gov/pubmed/19282834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2009.14
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