Trafficking-Deficient G572R-hERG and E637K-hERG Activate Stress and Clearance Pathways in Endoplasmic Reticulum

BACKGROUND: Long QT syndrome type 2 (LQT2) is the second most common type of all long QT syndromes. It is well-known that trafficking deficient mutant human ether-a-go-go-related gene (hERG) proteins are often involved in LQT2. Cells respond to misfolded and trafficking-deficient proteins by eliciti...

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Autors principals: Wang, Ying, Huang, Xiaoyan, Zhou, Jianqing, Yang, Xi, Li, Di, Mao, Haiyan, Sun, Huan Huan, Liu, Ningsheng, Lian, Jiangfang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252338/
https://ncbi.nlm.nih.gov/pubmed/22242185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029885
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