Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1

The most active anticancer component in green tea is epigallocatechin-3-gallate (EGCG). The human peptidyl prolyl cis/trans isomerase (Pin1) plays a critical role in oncogenic signaling. Herein, we report the X-ray crystal structure of the Pin1/EGCG complex resolved at 1.9 Å resolution. Notably, the...

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Bibliographic Details
Main Authors: Urusova, Darya V., Shim, Jung-Hyun, Kim, Dong Joon, Jung, Sung Keun, Zykova, Tatyana A., Carper, Andria, Bode, Ann M., Dong, Zigang
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244823/
https://ncbi.nlm.nih.gov/pubmed/21750208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0301
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