Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells

The Ldb1/GATA-1/TAL1/LMO2 complex mediates long-range interaction between the β-globin locus control region (LCR) and gene in adult mouse erythroid cells, but whether this complex mediates chromatin interactions at other developmental stages or in human cells is unknown. We investigated NLI (Ldb1 ho...

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Hauptverfasser: Kiefer, Christine M., Lee, Jongjoo, Hou, Chunhui, Dale, Ryan K., Lee, Y. Terry, Meier, Emily R., Miller, Jeffrey L., Dean, Ann
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Red Cells, Iron, and Erythropoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234672/
https://ncbi.nlm.nih.gov/pubmed/22010104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-363101
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