Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio

BACKGROUND: Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-O-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its selectivity on PDE4 and binding ability on high-affinity rolipram-binding...

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Autors principals: Yang, You-Lan, Hsu, Hsin-Te, Wang, Kuo-Hsien, Han, Cheng-Ying, Chen, Chien-Ming, Chen, Chi-Ming, Ko, Wun-Chang
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225327/
https://ncbi.nlm.nih.gov/pubmed/22074248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-84
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