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SIE calculations on molecular dynamics trajectories: Increasing the efficiency using systematic frame selection

End-point methods such as Linear Interaction Energy (LIE) analysis, Molecular Mechanics Generalized Born Solvent Accessible Surface (MM/GBSA) and Solvent Interaction Energy (SIE) analysis have become popular techniques to calculate the free energy associated with protein-ligand binding. Such methods...

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Bibliographic Details
Main Authors: Lill, Markus A., Thompson, Jared J.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212856/
https://ncbi.nlm.nih.gov/pubmed/21870864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci200191m
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