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Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice

Although preterm delivery is a major global health issue, its causes and underlying mechanism remain elusive. Using mutant mice, mimicking aspects of human preterm birth, we show here that uterine decidual senescence early in pregnancy via heightened mammalian target of rapamycin complex 1 (mTORC1)...

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Main Authors: Hirota, Yasushi, Cha, Jeeyeon, Yoshie, Mikihiro, Daikoku, Takiko, Dey, Sudhansu K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207648/
https://ncbi.nlm.nih.gov/pubmed/22025690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108180108
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