β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

OBJECTIVE: The role of uncoupling protein 2 (UCP2) in pancreatic β-cells is highly debated, partly because of the broad tissue distribution of UCP2 and thus limitations of whole-body UCP2 knockout mouse models. To investigate the function of UCP2 in the β-cell, β-cell–specific UCP2 knockout mice (UC...

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Main Authors: Robson-Doucette, Christine A., Sultan, Sobia, Allister, Emma M., Wikstrom, Jakob D., Koshkin, Vasilij, Bhatacharjee, Alpana, Prentice, Kacey J., Sereda, Samuel B., Shirihai, Orian S., Wheeler, Michael B.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2011
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198081/
https://ncbi.nlm.nih.gov/pubmed/21984579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0132
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