Synergy Between Intraepithelial Lymphocytes and Lamina Propria T Cells Drives Intestinal Inflammation During Infection

Oral infection of C57BL/6 mice with Toxoplasma gondii triggers severe necrosis in the ileum within 7–10 days of infection. Lesion development is mediated by Th-1 cytokines, CD4(+) T cells, and sub-epithelial bacterial translocation. As such, these features share similarity to Crohn’s disease. Recent...

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Main Authors: Egan, C. E., Maurer, K. J., Cohen, S. B., Mack, M., Simpson, K. W., Denkers, E. Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196813/
https://ncbi.nlm.nih.gov/pubmed/21796113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2011.31
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