Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells

We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced...

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Main Authors: Kim, Jun-Seob, Heo, Paul, Yang, Tae-Jun, Lee, Ki-Sing, Cho, Da-Hyeong, Kim, Bum Tae, Suh, Ji-Hee, Lim, Hee-Jong, Shin, Dongwoo, Kim, Sung-Koo, Kweon, Dae-Hyuk
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195057/
https://ncbi.nlm.nih.gov/pubmed/21844322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00708-11
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