mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR pathway causing pleiotropic cellular effects including an mTOR-dependent loss in insulin receptor substrate-1 expression leading to feedback down-regulation of signaling thro...

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Autores principales: O’Reilly, Kathryn E., Rojo, Fredi, She, Qing-Bai, Solit, David, Mills, Gordon B., Smith, Debra, Lane, Heidi, Hofmann, Francesco, Hicklin, Daniel J., Ludwig, Dale L., Baselga, Jose, Rosen, Neal
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193604/
https://ncbi.nlm.nih.gov/pubmed/16452206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-05-2925
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