Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates

The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor (TIR) adaptor, designated bbtTICAM, which was identified in the basal chordate amphioxus, links this pathway to invertebrates. The protei...

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Autors principals: Yang, Manyi, Yuan, Shaochun, Huang, Shengfeng, Li, Jun, Xu, Liqun, Huang, Huiqing, Tao, Xin, Peng, Jian, Xu, Anlong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193451/
https://ncbi.nlm.nih.gov/pubmed/21931360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.156
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