Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response

Recognition of viral RNA structures by the intracytosolic RNA helicase RIG-I triggers induction of innate immunity. Efficient induction requires RIG-I ubiquitination by the E3 ligase TRIM25, its interaction with the mitochondria-bound MAVS protein, recruitment of TRAF3, IRF3- and NF-κB-kinases and t...

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Main Authors: Arnaud, Noëlla, Dabo, Stéphanie, Akazawa, Daisuke, Fukasawa, Masayoshi, Shinkai-Ouchi, Fumiko, Hugon, Jacques, Wakita, Takaji, Meurs, Eliane F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192838/
https://ncbi.nlm.nih.gov/pubmed/22022264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002289
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